Robert A. Weinberg received his B.S. and Ph.D. degrees in biology from the Massachusetts Institute of Technology (MIT). He did postdoctoral research at the Weizmann Institute, Rehovot, Israel, and at the Salk Institute, LaJolla, California, and then returned to MIT in 1972. In 1982, he was appointed Professor of Biology at MIT. He is a founding Member of the Whitehead Institute for Biomedical Research, the Daniel K. Ludwig Professor for Cancer Research, and an American Cancer Society Research Professor at the Massachusetts Institute of Technology. He is an authority on the genetic basis of human cancer. He and his colleagues discovered the first human-cancer-causing gene - the Ras oncogene - and the first known tumor-suppressor gene - Rb, the retinoblastoma gene. The principal goal of his research program is to determine how oncogenes, their normal counterparts (proto-oncogenes) and tumor-suppressor genes function together in the complex circuitry that controls cancer cell growth. He is particularly interested in applying this knowledge to improve our understanding of the molecular mechanisms of cancer cell invasion and metastasis.