Application of numerous quantum concepts and principles of the well developed theories of rate coefficients in the velocity of chemical reactions, including quantum tunneling and various equilibriums, to the development of nanotechnology beyond nanometer‐accuracy in distance measurements at the single molecule level extends the analysis of results from distance measurements to time scale analysis that with combination of spectrometry and spectroscopy extends the knowledge of percentage distribution of elements that are heavier than iron in the birth of super novae and are too heavy to be produced by stellar fusion in comparision to lighter elements, like oxygen, carbon, or helium to time scale investigation of chemical reactions in neutron stars and supernovae to imply Rayleigh–Taylor and Richtmyer–Meshkov instabilities and break of spherical symmetry with consequently indicating concentration of pressures and energies in small regions. These theoretical results in combination with further application of turbulence Kolmogorov 5/3 time scale law combined with loophole free Bell tests that can result in thousands times difference could be applied to time differences evaluation. Further application of these and similar theoretical approaches can extend research to nanolevel investigations of the multitude of polymers shapes and could be further applied to DNA and RNA analysis.
Michael Fundator has completed his Alma mater at Rutgers University of New Jersey, USA. He became a winner of World Championship Award in Multidimensional Time Model last year. He has published more than 20 papers in reputed journals and has been serving as an editorial board member of American Journal of Theoretical and Applied Statistics and Journal of Mathematics of Scientific Research Group. He became a winner of last year World Championship in Multidimensional Time Model, and in the last 3 years. He chaired 6 Sessions, made 25 Presentations at different International, National, and Local Conferences, and published 6 Papers with National Academy Press, some of them with Molecular, Atomic, and Optical or Astrophysical Divisions of National Academy of Sciences, 5 in Academy Journal of Scientific Research, where one of the Editors-in-Chief has more than 450 publications in Material Sciences, 6 in JSM Proceedings, Journal of Chemistry and Chemical Engineering, and other different Journals and Publishing sites, e.g. preprints etc... Making the whole number of publications in the past 3 years around 25 Articles. He also participate in the Conferences, Sessions, and Workshops of the Division of Material Physics of the National Academies of Sciences, Engineering and Medicine.
Glass-forming molecular materials containing donor and acceptor moieties recently synthesized at the laboratories of the presenting author will be reported. Derivative of 3-(trifluoromethyl)benzonitrile and 3,3’-bicarbazole was found to exhibit both TADF and exciplex-forming properties. Warm-white OLED based on this material showed external quantum efficiency (EQE) of ca. 20 %. The derivative of acridan and dicyanobenzene was found to be efficient TADF-emitter exhibiting both thermally activated delayed fluorescence and aggregation induced emission enhancement. Green OLED fabricated using this emitter exhibited maximum current, power efficiency and EQE of 68 cd/m2, 62 lm/W and 22.5 %, respectively. A series of carbazole-quinoxaline-carbazole derivatives exhibiting TADF and mechanochromic luminescence properties were synthesized and studied. Green-blue to green-yellow TADF OLEDs fabricated by solution processing demonstrated EQE up to 10.9% and luminance of 16760 cd m-2. By utilization of the derivatives cyanophenyl and ditertbutylcarbazolyl substituted triphenylbenzene with the different substitution pattern as host and guest of the emissive layer, deep-blue OLED based on triplet-triplet annihilation with EQE of 14.1% were fabricated. Derivatives of thianthrene and benzophenone exhibited room-temperature phosphorescence and demonstrated oxygen sensing ability.
Prof. Juozas Vidas Gražulevičius is professor at the Department of Polymer Chemistry and Technology at Kaunas University of Technology. He is expert in the synthesis and investigation of organic semiconductors and emitters for optoelectronic applications. He has published more than 390 papers in international journals, which were cited more than 5900 times and five review articles (h=34). He is co-author of 25 international patents and 5 chapters of books. He is a full member of Lithuanian Academy of Sciences. He is a winner of two Lithuanian National Science Prizes and the prize for science of Baltic Assembly.
Ahmed Hegazi is currently a Professor of Microbiology and Immunology in the National Research Center, Egypt. Prof. Hegazi received his master’s degree in 1979 and his PhD in 1981. Hegazi's research work has been focused lately on bee products and their therapeutic effects. Hegazi organized and contributed to national and international research projects since 1977 and up till now; he has been the principal investigator on multiple research projects within the National Research Center. He has published 222 scientific papers and articles in national and international journals. He also served on the board of multiple national and international scientific journals. Dr. Hegazi is also the president of the Egyptian Environmental Society for Uses and Production of Bee Products, secretary of the Egyptian Society of Apitherapy, secretary general of the African Federation of Apiculture Associations, and a member of the International Apitherapy Commission (APIMONDIA).
Fluorinated phosphonates are presumably the closest mimics of naturally occurring biological phosphates. Potentiality of this class of teflon phosphonate molecules has long been recognized in areas, such as, medicinal chemistry for drug design and in chemical biology, where these constitutively phosphorylated molecules have been used as tools to answer key questions in cell signaling pathways. This talk will focus on a new chemoenzymatic approach for the facile and stereoselective synthesis of densely functionalized Î´-thio-Î²,Î³-unsaturated-Î±,Î±difluorophosphonate building blocks. In a related work, a methodology for the efficient synthesis for allyl ester bearing Î±,Î±-difluorinated phosphonates was developed. In application, this methodology was used to generate a set of bis-phosphonate PTP1B (Protein Tyrosine Phosphatase 1B) inhibitors with low to moderate micromolar inhibitions, targeting Type-II diabetes.
Dr. Kaushik Panigrahi is an accomplished senior scientist in the analytical drug development division of Fresenius Kabi USA. He is a well-known expert in several areas of organic synthesis and medicinal chemistry, such as, fluorinated phosphonates, enzymatic organic synthesis, phosphono-amino acid synthesis and asymmetric catalysis. After completion of his doctoral studies in medicinal chemistry from University of Nebraska, Dr. Panigrahi started his postdoctoral studies on the pre-clinical drug target validation for celiac disease in a NIH-funded joint collaborative investigation by two prestigious institutions in the US, University of Chicago and Stanford University. During his academic journey, Dr. Panigrahi has published in high-impact journals with international circulations, such as, Nature, Journal of the American Chemical Society (JACS), etc. Currently, Dr. Panigrahi is also serving as a member of the editorial board of referees for ARKIVOC, an organic chemistry journal.
The world has seen a rapid growth in the number of Technology Transfer professionals in the last decade, serving the knowledge base in industry, government and educational organizations. Technology transfer professionals, typically manage the complex process of shepherding ideas from the lab to the marketplace. From evaluating and protecting discoveries to commercializing the inventions through new and existing companies. Employment and growth prospects for professionals and young talents in the field of Intellectual property, and its applications in the corporate and academic world are also extremely bright throughout the world. This presentation will offer to explain the role of Technology transfer, describe its impact, and direct young talents to career opportunities in the field.
Joy is the Assistant Director of the Office of Economic Innovation and Partnerships, where he oversees and manages technology transfer activities and corporate partnerships for the University of Delaware. Among his other roles, Joy is actively involved in managing intellectual property, assisting in establishing start-up and spin-off companies and bringing forth university-industry collaborations & partnerships. He has more than twenty years of experience in the field of business development and a career that has produced highly regarded commercialization strategies and outreach practices of novel technologies in chemical engineering, biotechnology, agriculture and bio-medical sector. Joy is a Registered Patent Agent for the US Patent & Trademark Office. He is also a Small Business Innovation Research (SBIR/STTR) reviewer for the National Institutes of Health (NIH) and a Howard Bremer Scholar. Joy earned his Bachelor’s and Master of Science in Biology from Delhi University South Campus, and his MBA from the Herberger’s College of Business, St. Cloud State University, Minnesota, USA. He earned his Registration as a Technology Transfer Professional (RTTP) from the Alliance of Technology Transfer Professionals.
Introduction: we have recently developed the concept of total daily life philosophy (TDLP) which implies that in science we should adopt thinking and perceive scientific issues from various points of view. Taking this philosophical approach into consideration, I have developed cell rehabilitation project in which both chemical and biological perspectives are taken together to find new therapeutic remedies. In this approach, we have postulated that cell is still working, but due to chemical interrupting chemicals, cell has been deviated from its functions, that can be restored. Study objectives: the main objectives of this study are to introduce chemical and biological features of cell rehabilitation project and to show our experience in applying this project in treating two of most common chronic diseases: renal failure and diabetes type 2. Cell rehabilitation program: both of Urtica pilulifera and Ammi visnaga have therapeutic potential in traditional medicine. We have previously used both in animal models to treat diabetes and in clinical cases. Our findings suggested that their influence the expected results. The idea has come to include them in a more wide scope. It is how to return cells to approximately normal situation. This is what I called rehabilitation. In first trial of experiments, approximately 30 cases of pre-diabetic cases restored their normal glucose levels after two weeks of using aqueous solution of Ammi visnaga. In the second group of experiments, I was able to successfully treat 20 cases of chronic renal failure cases using both Urtica pilulifera and Ammi visnaga for 21 days. Patients were either to start renal dialysis as recommended by their treating physicians, or they were already engaged in renal dialysis. Taken together, in both groups of patients levels of creatinine and urea were dramatically decreased to safe levels.
Dr. Ahed Alkhatib has finished his PhD from Cambell State University in 2011. I am currently working as a clinical researcher at faculty of medicine, Jordan University of Science and technology. Over the time, I have published more than 200 articles in various medical fields including neurosciences, pharmacology, and diabetes. My approaches in research include the involvement of philosophy of science in research which gives looking, and thinking in depth. I have developed several hypotheses in medicine such as the role of white matter in initiating diseases such as diabetes. In microbiology, I have demonstrated that prokaryotic cells and eukaryotic cells are similar in producing cell cycle proteins which can participate in autoimmunity diseases.
Catalytic pyrolysis of waste plastics using 5 M sulfuric acid treated kaolin clay catalyst in a stainless steel reactor has provided liquid hydrocarbon. The yield and density of the liquid are 50.94% and 0.7953 g/mL respectively. The GC-MS, 1H NMR, and FTIR analysis show that the liquid hydrocarbon mostly contains linear and branched alkanes and alkenes having carbon number C9-C20. The compounds that are predominantly present in the liquid product are: 2,3-dimethyl-2-heptene; 2,4-dimethyl-1-heptene; 2,4,6-trimethyl-3-heptene; 3,3-dimethyl-octane; 2,4-dimethyl-2-decene; 2,2-dimethyl-3-decene; 4,5-dimethyl-2-undecene and eicosane. The composition, structure and morphology of the catalyst have been analyzed by XRF, XRPD and SEM. The BET experiment shows that both Si/Al ratio and surface area have increased after sulfuric acid treatment from 1.79 to 3.48 and 6.85 m2/g to 17.92 m2/g respectively. The nitrogen adsorption-desorption isotherms of the acid treated kaolin clay shows the isotherm is type IV. This type of isotherm is typical for mesoporous structure.
Dr. Mohammed Mahmudur Rahman is an Assistant Professor, Department of Chemistry, Jagannath University, Dhaka, Bangladesh. Dr. Rahman earned his PhD in Chemistry from the University of Edinburgh, UK. He was awarded EaStCHEM scholarship from the University of Edinburgh, UK for his PhD to develop zwitterionic catalyst for alkene polymerization using 6- aminofulvene-2-aldiminate (AFA) ligand by mimicking cationic Brookhart catalyst. Dr. Rahman gained his MSc degree in Chemical Engineering from Eindhoven University of Technology, the Netherlands. He did internship on fluid cracking catalysts in Albemarle Catalysts Company BV, Amsterdam, the Netherlands. He completed his BSc (Hons) & MSc degree in Chemistry from Shahjalal University of Science & Technology, Sylhet, Bangladesh. Dr Rahman has experience on synthesis of organometallic complexes and catalysis, and catalytic pyrolysis of waste plastics into liquid hydrocarbon.
Prof. Solhe F. Alshahateet is a Professor of Organic and Supramolecular Chemistry graduated in 2003 from the University of New South Wales (UNSW, Australia). Currently, he is the president of Aqaba University of Technology (AUT, Jordan). He works as a Full Professor at Mutah University (Jordan) since 2007. He received many awards such as Australian Research Council and Jordanian Ministry of Higher Education scholarships. He engaged in many projects from local and international funding agencies. Prof. Alshahateet attended many conferences worldwide. He published more than 73 articles mostly in international journals dealing with crystal engineering and supramolecular chemistry involving industrial applications. In addition, he is working as a referee and editorial board member for many international specialized journals. Highlights of his research have been in the area of synthesis and characterization of semiconducting materials, organic materials for and industrial applications (functional materials) such as pharmaceutical industry. After completing his PhD (2003) at the UNSW, he undertook research in new synthesis chemistry as a Research Fellow at UNSW for about one year. Since then he had undertaken research into synthesis of new organic materials at the Institute of Chemical and Engineering Sciences ICES, Singapore. He had research visitor appointments at the University of New South Wales (Australia) and at the University of South Florida (USA).
In the present era, celiac disease has become an alarming issue due to growing number of genetically susceptible people with gluten intolerance. The pathogenesis of this intestinal inflammatory disorder has been implicated with ubiquitously expressed transglutaminase 2 (TG2). Till date, there is no drug in the market for treatment of this disease. The only alternative is to adhere a gluten-free food which is relatively expensive than regular food and at the same time not easily available everywhere. Earlier, the Khosla lab has reported a set of irreversible (S)-dihydroisoxazole (DHI) inhibitors for activated TG2 (Khosla et al., J. Med. Chem, 2014). In vitro SAR studies and in vivo wild-type (WT) mouse model pharmacokinetic studies (oral- and IP-dosing) have pointed out some early leads for further investigations. This talk will cover the latest ground-breaking findings in this area that can potentially lead to the first time drug for the treatment of this disease.
Phyto- and myco-remediation have been identified as sustainable options for treatment of petroleum contaminated soils. To appraise the benefits thereof, the potentials of 3 sunflower species, 2 palm wine types and P. ostreatus to treat petroleum-contaminated soils was investigated. The study involved sampling of petroleum-contaminated soils and treatment with phyto- and myco-remediation agents for a period of 90-days. Agents used for the remediation were 3 species of sunflowers (Helianthus annus-pacino gold, Helianthus sunsation & Helianthus annus-sunny dwarf), fermented palm wine (from 2 species of palm trees -Elaeis guineensis & Raffia africana), and oyster mushroom (Pleurotus ostreatus). The investigation revealed up to 339 g/kg dry weight of Total petroleum hydrocarbons (TPHs) in the soils, with remediation outcomes of up to 69% by the sunflower- Helianthus annus (Pacino gold), 70% by fermented palm wine, and 85% by P. ostreatus. While the remediation efficiency of sunflower species was proportional to biomass, there was no significant difference in remediation efficiency of the palm wines. It was also found that substrates type and method of application has a significant impact on the remediation efficiency of P. ostreatus. The study further revealed available nitrate and electrical conductivity as possible useful indicators of TPHs concentration and remediation progress in soils. Keywords: Total Petroleum Hydrocarbons, Sunflower species, Palm wine, Pleurotus ostreatus, Petroleum-contaminated soil, Soil remediation.
The study includes research on Hardox 400, 450 steel material using CO2 laser cutting. The design of the experiment consisted of a cut-off plan reduced to 9 observations from a factorial experiment 33 following a certain rule, using the Taguchi optimization method, which was subsequently replicated 4 times to the same values of the input parameters (laser power, gas pressure, cutting speed), obtaining 45 pieces. The energetic quantities were calculated which are shock factors influenced by the laser energy, respectively the linear energy El or the energy of the cut surface Es for a linear or elliptical contour that delimits the piece. The experimental and statistical results indicated that the most important cutting parameter is the speed using a matrix array for calculating the 2k type effect. Laser cutting of Hardox steels is used in the manufacture of chassis, excavator arms, construction of ferries, barges, tanks, amphibians. Of particular interest is the equation that describes the heat released due to the irradiation of the laser material and the thermochemical reaction of Fe with O2 Oxygen. In the experimental work we used the RX Spectrometer to determine the chemical composition of the cut surface and to perform a statistical calculation for H400, H450, respectively scientific interpretations and comparisons. The obtained results show that the microstructure of the cut surface, the physical and chemical properties for the cut parts under the same conditions, with the identical variable parameters is different for the pieces made from H450, an impact that indicates the characteristics of difficult laser cutting to sheets with larger thicknesses. Experimental laser cutting research is consistent and determined by theoretical ones.
In addition to previously presented scientific work, modified reaction sequence of Fischer-Tropsch (FT) process was studied by addition of Zeolite ZSM-5 to an iron-based activated-carbon-supported catalyst. Main reactions involved due to FT catalyst are Fischer Tropsch Synthesis (FTS) and Water Gas Shift (WGS) reactions. Main reactions due to ZSM-5 are cracking, oligomerization, isomerization, cyclization, aromatization, conversion of alcohols to hydrocarbons, and coke formation. The waxy and linear structure FT products are converted to gasoline range, lighter hydrocarbons, iso-paraffins, and aromatics using ZSM-5. The catalyst ratio of 1:2, FT catalyst: ZSM-5, is used at 300 PSIG and 300°F. Separate-bed configuration, i.e. FT and ZSM-5 are separated in a reactor, arrangement is used for the reaction sequence analysis. Alcohols with carbon-chain from 3-5 produced by FTS are converted into hydrocarbons over ZSM-5. Waxy hydrocarbons with carbon-chain greater than 23 produced by FTS are cracked and isomerized to small n-paraffins and iso-paraffins using ZSM-5. The hydrocarbon with carbon chain from 7-10 produced by ZSM-5 cracking reactions are converted to aromatic products over ZSM-5. Produced gasoline to kerosene range n-paraffins are further cracked into smaller chain (1-5) iso- and n-paraffins. Some of the iso-paraffins are oligomerized and aromatized over ZSM-5 to form more aromatics. Further, multiple aromatic rings combine to undergo cyclization and dehydrogenation reactions over ZSM-5 to form coke. Water produced as a byproduct of FTS is combined with some of the carbon monoxide, which is the WGS, to form carbon dioxide and hydrogen.
A theoretical study of hemiacetal synthesis from formaldehyde with methanol catalyzed by Brönsted acids from the analysis of intermediate of the reaction was carried out. The study of acetalization of aldehydes is of great interest by the utility of its products of reaction and is one of the most frequently used transformations in organic synthesis as it provides an efficient means for protecting carbonyl groups in a synthetic process. Acetalization of aldehydes is a nucleophilic addition reaction. This reaction can be catalyzed by Brönsted acid. In the mechanism, the aldehyde first accepts a proton at the carbonyl oxygen and this change enhances the positive charge on the carbonyl carbon. This facilitates the successive attack nucleophilic of alcohol at the position to form a tetrahedral intermediate, step determinant of the rate of the reaction. Experimental studies were carried out and agreed that this reaction takes place with the formation of a tetrahedral intermediate. In the present theoretical work were investigated the structure and energy of the tetrahedral intermediate of the reaction catalyzed by Brönsted acid. Geometries of all species involved in the hemiacetal synthesis were made and identified. All of the geometry optimizations were performed by the method at the DFT/B3LYP level of theory and were adopted the 6-31+G* basis sets. Following the same procedure it was identified the geometric parameters and energy of reaction intermediate. The energy of activation for the reaction was 6.21kcal/mol coinciding with theoretical studies.
The evaluation of pharmaceutical raw materials and finished products for impurities and degradation products is an essential part of the drug development and manufacturing testing process. Additionally, toxicological information must be obtained on any drug-related impurity that is present at a concentration of greater than 0.1% of that of the active pharmaceutical ingredient (API). In pharmaceutical QC and manufacturing, impurity analysis has traditionally been performed by HPLC with UV, PDA, or MS detection. As it is essential to detect and measure all of the impurities in the sample, it is necessary to have a high resolution separation process. This usually involves long analysis times resulting in low throughput. As candidate pharmaceutical compounds become more potent and are dosed at lower and lower levels, ever more sensitive assays are needed to detect and measure impurities. The low throughput of HPLC can become the rate-limiting step in product release testing or process evaluation. Since much of the process of impurity identification involves the coupling of LC to sophisticated MS, any reduction in analysis time will result in a more efficient use of these significant investments. Analytical technology advances such as UPLC and UPC offer significant improvements in throughput and sensitivity, with benefits to the process of product release and identification of drug-related impurities. The most characteristic feature of the development in the methodology of pharmaceutical and biomedical analysis during the past 25 years is that HPLC became undoubtedly the most important analytical method for identification and quantification of drugs, either in their active pharmaceutical ingredient or in their formulations during the process of their discovery, development and manufacturing.