Dr. Yoshiaki Omura received Oncological Residency training at Cancer Institute of Columbia University & Doctor of Science Degree through research on Pharmaco- Electro-Physiology of Single Cardiac Cells in-vivo and in-vitro from Columbia Uni.. He researched EMF Resonance phenomenon between 2 identical molecules for non-invasive detection of molecules, at Graduate Experimental Physics Dept., Columbia Uni., for which he received U.S. patent. He is also the creator of Bi-Digital O-Ring Test. He published over 270 original research articles, many chapters, & 9 books. He is currently Adjunct Prof. of Family & Community Medicine, New York Medical College; President & Prof. of Int’l College of Acupuncture & Electro-Therapeutics, NY; Editor in Chief, Acupuncture & Electro-Therapeutics Research, Int’l Journal of Integrative Medicine, (indexed by 17 major int’l Indexing Periodicals); Formerly, he was also Adjunct Prof. or Visiting Prof. in Universities in USA, France, Italy, Ukraine, Japan, Korea, & China.
Dr. Milan Sonka received his Ph.D. degree in 1983 from the Czech Technical University in Prague, Czech Republic. He is Associate Dean for Graduate Programs and Research of the College of Engineering at the University of Iowa, Professor of Electrical & Computer Engineering, Professor of Ophthalmology & Visual Sciences, and Radiation Oncology, Co-director of the Iowa Institute for Biomedical Imaging, IEEE Fellow, AIMBE Fellow, and MICCAI Fellow. His research interests include medical imaging and knowledge-based image analysis with emphasis on cardiovascular, pulmonary, orthopedic, cancer, and ophthalmic image analysis. He is the first author of 4 editions of Image Processing, Analysis and Machine Vision book (1993, 1998, 2008, 2014) and co-authored or co-edited 20 books/proceedings. He has published more than 180 journal papers and over 430 other publications. He is past Editor in Chief of the IEEE Transactions on Medical Imaging and member of the Editorial Board of the Medical Image Analysis journal. To bring results of his research work to clinical practice, he has co-founded two medical imaging companies -- Medical Imaging Applications LLC, and VIDA Diagnostics Inc.
Dr. Yaping Tian was the Professor and Director of translational medicine laboratory, Chinese PLA General Hospital. Dr Tian received his Master Degree in Medicine from Chinese PLA Postgraduate Medical School in 1989 and PhD from Academy of Military Medical Sciences in 1993. He had been trained as Postdoctoral Fellow for 2 years(1995-1997) in The Queen Elizabeth Hospital, Australia. Dr. Tian has been focusing on the study of the specific serum proteomic profiles and genetic signatures in different diseases, especially on cancer and cardiovascular diseases. Dr. Tian has received more than 20 grants and published more than 400 scientific papers in peer-reviewed journals.
Dr. Dao Wen Wang has received his PhD from Tongji Medical University during the period of 1992. Currently, he is working as Professor in Huazhong University of Science & Technology.
Dr. Shao Lin has completed her PhD from University of North Carolina at Chapel Hill, USA. She is a professor at the Department of Environmental Health Sciences and an associate director of Global Health Research, State University of New York at Albany. She has been awarded multiple grants from NIH and published more than 130 peer-reviewed papers in reputed journals. Her postdoctoral fellow, Dr. Wangjian Zhang, obtained his PhD from Sun Yat-sen University, China, and has published more than 50 peer-reviewed papers in reputed journals.
Xiaoqing LIU is a Chief cardiologist and epidemiologist, director of epidemiology department, director of WHO collaborative center for research and training in cardiovascular disease. She has completed her doctor degree from Guangdong university of Pharmaceutical in-1985. She is a trained epidemiologist and has a major interest in disease risk factor, evaluation of post intervention and community control of cardiovascular disease. Since 2010 she begins focus her research on congenital heart disease(CHD) both in neonate and adult. Including risk factors, post intervention evaluation, multi-center registration, setting up database, patient’s management and education.
Dr. Salah A. Mohamed is an Associate professor of Experimental Cardiac Surgery. The academic journey leads to PHD and Training, at the Institute of Legal Medicine and Laboratory/Group Leader in the Department of Cardiac and Thoracic Vascular Surgery. He has published in different reputed scientific journals in the topics of aortic and aortic valve disease, Genetics, and biomarker discovery. His laboratory also focuses on understanding the causes of atrial fibrillation. He sits on the editorial boards of many scientific and medical journals.
Xiushan Wu completed his PhD from Stockholm University in 1986-1990, postdoctoral studies from Michegan University and etc in 1990-1994 and Scientist in Karolinska Institute in 1994-2000. He is the Director and Professor of The Center for Heart Development, Hunan Normal University. His research focuses on understanding the mechanisms by which embryonic heart is developed using Drosophila, zebrafish and mice as models. He has published more than 350 papers including over 110 SCI papers.
Arlette Perry, Director, Laboratory of Clinical and Applied Physiology, University of Miami. Dr. Perry’s research has focused on cardiometabolic health in women with an emphasis on the role of exercise in the reduction of cardiovascular risk factors. Recent studies have focused more on the impact of visceral adipose tissue on cardiometabolic health, how that may differ by race, and it’s relationship to the sex steroid milieu in premenopausal women. Currently she is examining how a translational health program can increase physical fitness and physical literacy while reducing adiposity in minority children.
Dr. Kunlun He from Chinese People's Liberation Army General Hospital, is dedicated to basic and clinical research of cardiovascular diseases, especially genomics of heart failure and drug research on pulmonary hypertension. Currently engaged in artificial intelligence research of cardiovascular imaging.
Dr. Ming-Yow Hung as an associate professor of medicine, and director of cardiac catheterization laboratory, shuang ho hospital, Taipei medical university, he has studied CAS and aortic stenosis for >10 years, during which time he has authored more than 40 peer-reviewed reports. Recent published papers include Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 2018;558(7709):301-306, Activation of the Monocytic α7 Nicotinic Acetylcholine Receptor Modulates Oxidative Stress and Inflammation-associated Development of CAS via a p38 MAP-Kinase signaling-dependent pathway. Free Radical Biology & Medicine 2018;120:266-276, and CAS as Related to Anxiety and Depression: a Nationwide Population-Based Study. Psychosomatic Medicine 2019 Jan 15.
Dr. Amit Bansal has completed his medical education from Delhi Universty, India and Internal Medicine residency from Johns Hopkins University, Baltimore, MD. He is currently working as Senior Hospitalist attending and Director of Quality for Rochester General Hospitalist Group at Rochester Regional Health, Rochester, NY.
Dr. Ramachandran Muthiah Published many papers in Cardiosource, American College of Cardiology Foundation, Case Reports in Clinical Medicine (SCIRP) and Journal of Saudi Heart Association. Special research on Rheumatic fever and Endomyocardial fibrosis in tropical belts, Myxomas, Infective endocarditis, apical hypertrophic cardiomyopathy, Ebstein’s anomaly, Rheumatic Taussig-Bing Heart, Costello syndrome and Tetralogy of Fallot.
Dr Li Ni earned her MD (2004) and PhD (2009) degrees from Tongji Medical College, Huazhong University of Science and Technology, in China. She practices cardiology in Tongji Hospital, one of the leading teaching hospitals in China. She has been a visiting scientist in Dr Xander Wehrens’s lab (2016-2018). She published several papers as first author in high impact journals such as Circulation Research, Stroke and Molecular Pharmacology. She has got two grants from the National Natural Science Foundation of China as the principle investigator.
Dr. Liangdi Xie has completed his PhD from Xiangya School of Medicine, Central South University, China. He is working in the First Affiliated Hospital of Fujian Medical University, and working as the director of Fujian Hypertension Research Institute and the vice editor-in-chief of Chinese Journal of Hypertension. He has published more than 100 papers (Chinese and English) as the first author or corresponding author in the field of cardiology, as well as a book of hypertension. Dr. Xie is also the fellow of American College of Cardiology (FACC) and the vice chairman of Hypertensionist of Chinese Medical Doctor Association (CMDA).
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Dr Amit Bansal has completed his medical education from Delhi Universty, India and Internal Medicine residency from Johns Hopkins University, Baltimore, MD. He is currently working as Senior Hospitalist attending and Director of Quality for Rochester General Hospitalist Group at Rochester Regional Health, Rochester, NY.
Dr. AbuRuz got his the PhD in cardiovascular nursing from the university of Kentucky in 2006. He worked as an assistant professor at facluty of medicine at Sultan Qaboos University, Muscat, Oman and Dammam University, Dammam, Saudi Arabia. He also worked as the director of nursing education at King Fahad specialist hospital dammam, Saudi Arabia. Currently he is working as an associate professor at applied science university in Amman, Jordan Dr. AbuRuz co-authored the textbook of cardiac nursing edited by Debra Moser and Barbara reigel. Dr, AbuRuz has more than 60 publications international journals and he is a reviewer for the Journal of Cardiovascular Nursing.
Shouhartha Choudhury has completed his B.Tech, M.Tech in Bioinformatics and M.Phil in Life Science and Bioinformatics from India, and pursuing Ph.D. in Biotechnology at Assam University, Silchar, Assam, India. He is a research scholar in the School of Life Sciences, Department of Biotechnology, Assam University, Silchar-788011, Assam, India. He has published a paper entitled “Comparative analysis of Bcl-2 family” in the journal of Bioinformation. He received 15 abstract acceptance letters from the International Conference 2019.
Dr. Yaniel Castro-Torres was graduated as a Medical Doctor from Universidad de Ciencias Médicas de Villa Clara, Cuba. He gained a Medical Degree as Specialist in Cardiology from the same university. He has published 27 medical papers in reputed journals and participated in 19 scientific congresses. He has been awarded with the best Oral Presentation at two international medical meetings and has received recognition from several health organizations.
Renata Balbino is a Registered Nurse specialized in Primary Care Education and coaching to Home Health Care professionals. As a Primary Care Nurse and CEO of Dedicare Cuidados Integrais I`m always looking for ways to prevent and care for health including cardiovascular diseases. I will present a case report on how to use children to help their families on preventing cardiovascular illness.
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Dr Danilo Galantini has completed his PhD from Instituto DANTE PAZZANESE de Cardiologia, Sao Paulo, Brazil and is performing his postdoctoral studies at the Heart Institute of The University of Sao Paulo, Brazil. He is specialist in advanced heart failure, heart transplantation and mechanical circulatory support and has been working for seven years in this field by the Projeto Coração Novo of the Ministry of Health of the Brazilian federal government.
Mr. Shan Sharma, BCA, MBA, Associates of BS has over the past 17 year participated in numerous global efforts to introduce and induce new transformative technology breakthroughs in a myriad of agricultural, automation and electronic applications of technology worldwide. He was awarded the International Business development leadership award in 2007 for his leadership in deploying animal identification radio frequency technology across Asia pacific and beyond. He has contributed to numerous organizations, public private partnerships and numerous national programs through software and technology including specialized semiconductor technology across the world since 2005 including the USA since 2012. He is the Business Development Principal and NFC evangelist, at Silicon Craft Technology PLC a publicly listed company with a global foot print in pioneering transformative technologies as a Semiconductor product and service organization with which he has been associated for over 14 years.
Wangjian Zhang obtained his PhD from Sun Yat-sen University, China, and has published more than 50 peer-reviewed papers in reputed journals.
Saed Al Nobani still as student in his DNP at the age of 35 years i completed my MSN from Liverpol University and Bachelor degree in Nursing from jordan university . He is the Manager of Education & life support in Enaya Hospital/ Enaya medical group In KSA-Dammam, he is certified as Patient safety officer from American institution of healthcare Management , He has published more than 3 papers in jordan about quality, patient saftey & waste managment
Cytomegalovirus infection in a patient with new onset systemic lupus erythematosus and acute myocardial infarction – cause or causal relationship?Biography
Anum Asif has completed his MD from Saint Agnes Hopsital, USA and currently is facult at department of medicne. Her ares of interest is role of inflammaorty conditions in the developement of coronary artery disesae and impact of coronary arytyery disease on women health. She is currently researching role of spiritual care in patients of advance heart failure.Abstract
The possible role of infectious and inflammatory states in the pathogenesis of atherosclerotic disease has been a matter of debate in the literature. There are case reports of active cytomegalovirus (CMV) infection unmasking underlying dormant systemic lupus erythematosus (SLE). CMV infection has also been postulated to be associated with atherosclerosis development in the coronaries. We present a unique case where a patient with newly diagnosed SLE and acute myocardial infarction (AMI) was found to have high anti-CMV titers suggesting concomitant active CMV infection. Although an association between CMV infection and atherosclerosis has been postulated in the past, there are no studies available that have established a causal relationship. It is important to identify these patients early and work on risk factor modification; it might also be prudent to refer them to preventive cardiology for close follow up. We believe it is reasonable to routinely check CMV titers in patients with underlying inflammatory conditions like SLE or other related autoimmune diseases; these patients could then be followed prospectively to see if causality could be established.
Ectopic Atrial Rhythm Presenting as CardiomyopathyBiography
Dr. Mohammad Abu Sheikha has completed his MD from University of Jordan, Jordan and currently is doing his internal medicine residency at Rochester General Hospital, NY, USA.Abstract
A 67-year-old male presented with palpitations and fatigue. Workup revealed atrial fibrillation (AF) and non-ischemic cardiomyopathy with ejection fraction (EF) of 45%. He underwent valvular repair and Maze procedure. Six months later he was found to have persistent atrial flutter with a new EF of 25%. He underwent 2 ablations resulting in termination of his arrhythmia, but his EF remained low. A ZIO monitor showed high premature ventricular complex (PVC) burden and mean heart rate of 90 bpm despite maximal dose beta-blockers. An EP study revealed PVCs of multiple morphologies and it was noted that his underlying rhythm had a constant cycle length of 670 msec. Both atria were mapped. Earliest activation was at the left atrial appendage propagating rightwards, activating the right atrium and returning to the left atrium through the coronary sinus. Fractionated electrograms of 115 msec were recorded. Ablation at the site terminated the patient’s ectopic rhythm and he converted to sinus bradycardia. Three months later, his EF improved to 55% and symptoms were ameliorated.
Arrhythmogenic Right Ventricular Dysplasia Elucidated by Genetic TestingBiography Abstract
Background: Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) is a heritable disease characterized by fibro-fatty replacement of the right ventricle (RV) myocardium, leading to potentially fatal arrhythmias. It is diagnosed using a combination of major and minor criteria.
Case: A 40-year-old woman with no prior cardiac history was seen for chronic intermittent palpitations. These have become more frequent over the past year, occurring with exercise. An ECG revealed small positive deflections following QRS complexes, non-specific T-wave inversions and multifocal PVCs. Stress echo showed normal anatomy, but the patient developed palpitations with increasing PVCson ECG (Figure 1). She was thought to have Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), with ARVD/C deemed less likely after a normal Cardiac MRI (CMR). Genetic testing for CPVT returned negative but identified a plakophilin-2 (PKP2) gene mutation pathogenic for ARVD/C. Repeat CMR in 6 months revealed an akinetic RV and marked thinning of the RV free wall consistent with ARVD/C. The patientreceived a subcutaneous ICD and was educated on exercise restriction.
Discussion:There should be a high level of suspicion for ARVD/C in patients with congruent symptoms and characteristic ECG changes. While genetic testing is not frequently utilized, it was invaluable in this case where cardiac structure and function were normal on imaging. PKP2 is one of many genes associated with risk of developing ARVD/C. Regular, strenuous exercise can precipitate symptomatic electrophysiological changes in these individuals.
Isolated Right Ventricular Involvement with Sparing of Left Ventricle in a Patient with Cardiac Sarcoidosis and Complete Heart Block: rare and atypical presentationBiography
Dr Amit Bansal has completed his medical education from Delhi Universty, India and Internal Medicine residency from Johns Hopkins University, Baltimore, MD. He is currently working as Senior Hospitalist attending and Director of Quality for Rochester General Hospitalist Group at Rochester Regional Health, Rochester, NY.Abstract
Background: In cardiac sarcoidosis, complete heart block with left ventricular (LV) involvement can be seen with or without coexisting right ventricular (RV) involvement but isolated RV involvement is very rare.
Objective: This abstract highlights an atypical presentation of cardiac sarcoidosis with complete heart block and isolated RV involvement.
Results: A 40-year-old man with no significant past medical history presented with syncope. Electrocardiogram showed complete heart block (CHB). Complete blood count, basic metabolic panel, troponin I, urine drug screen, thyroid stimulating hormone, Lyme and Syphilis serologies were unrevealing. Transthoracic echocardiogram (TTE) showed left ventricular ejection fraction (LVEF) of 60%. Cardiac magnetic resonance (CMR) did not show any evidence of late gadolinium enhancement (LGE) or arrhythmogenic RV dysplasia. Dual-chamber pacemaker was implanted for CHB. Tc-99m Sestamibi myocardial perfusion imaging (MPI) and a fasting F18 fluorodeoxyglucose (FDG) metabolism cardiac sarcoid positron emission tomography (18F-FDG PET) study revealed intense multifocal uptake in the RV apical, free wall and septal regions with no uptake in the LV; and paradoxical septal motion with preserved septal thickening. LVEF was 56 %, RV size and function was normal. Increased uptake was also noted in scattered bilateral pulmonary nodules, mediastinal and bihilar lymph nodes, in caudate lobe of liver and spleen. Bronchoscopy with fine needle aspiration cytology of mediastinal lymph nodes revealed non-caseating granuloma. Purified protein derivative (PPD) testing for tuberculosis was negative. Patient was diagnosed with cardiac sarcoidosis involving RV but sparing LV and was started on methotrexate 10 mg weekly.
Conclusion: In a younger patient presenting with complete heart block, a high suspicion of cardiac sarcoid should be considered. 18F-FDG PET is critical for diagnosis when CMR is negative for LGE. Cardiac sarcoidosis with isolated RV involvement is rare and can be seen with sparing of the left ventricle.
Glycation by Glucose and Ketone Bodies of Aminophospholipids from Human Aorta is Inhibited by L-Arginine and Creatine’Biography
José D. Méndez, graduated from National Autonomous University of México (UNAM), he obtained his B. Sc. Degree in Chemistry at the School of Chemical Sciences with honorable mention. Later, he obtained his M. Sci. Degree in Molecular Biology and Ph. D. in Biochemistry at the School of Medicine (UNAM).
Dr. Méndez is senior researcher of the Medical Research Unit in Metabolic Diseases, National Medical Center, Mexican Institute of Social Security (IMSS), Mexico. His current major research interest is in Biochemistry of Diseases, especially in diabetes mellitus and its complications.
He has published several papers that including 158 articles, 20 chapters in books. He is author of three books and co-author of other three books.
The aim of this study was to evaluate the in vitro effect of L-arginine and creatine on glycation of aorta aminophospholipids by glucose and ketone bodies. Aminophospholipids were isolated from human aorta. Emulsions were prepared in 0.1 M phosphate buffer, pH 7.4 containing 11 mM glucose, 3 mMβ-hydroxybutyrate or 3 mM acetoacetate, respectively. When the effect of L-arginine or creatine was tested, 10 mM concentration was used. Emulsions wereincubated at 37 °C in dark during 61 days. Sampling was done on days 0, 12, 19, 26, 48 and 61. Samples were analyzed by thin layer chromatography, fluorescence and ultraviolet spectroscopy. Several spots were revealed; three spots with Rfvalues of 0.12, 0.17, and 0.244, respectively, showed higher intensity. Other spots with lower intensity were also revealed. Glycation was higher for glucose followed by β-hydroxybutyrate and acetoacetate. Given the intensity of the spots, the interaction of L-arginine is clear in mixtures containing aminophospholipids, glucose and β-hydroxybutyrate. On the other hand, less relative fluorescence was observed when creatine was added. This effect was better when glycation was caused by acetoacetate, while L-arginine effect was better on samples containing β-hydroxybutyrate. The spectral signals suggest the formation of several compounds between aminophospholipids, glucose and ketone bodies.
In conclusion, this study shows by three ways that high concentrations ofglucose and ketone bodies react with aortic aminophospholipids. Since cardiovascular disease has been associated with glycation process, this could be prevented with creatine or its precursor, L-arginine.
Systematic Review and Meta-analysis: Impact of Antithrombotic Regimens on Outcomes after Endovascular Interventions for Critical Limb IschemiaBiography
Amol K. Gupta completed Medical School (MBBS) from Post-Graduate Institute of Medical Sciences, Rohtak, India. Currently working as Clinical Researcher at the Heart, Vascular and Leg Center in Bakersfield, CA.Abstract
Endovascular intervention is often used totreat critical limb ischemia (CLI). Post- intervention treatment with antiplatelet and/or anticoagulant therapy has reduced morbidity and mortality due to cardiovascular complications. We reviewed literature comparing outcomes after antithrombotic treatment for patients with CLI. We characterized comparative antithrombotic therapy into three categories: 1) mono-antiplatelet therapy (MAPT) vs dual antiplatelet therapy (DAPT), 2) MAPT vs antiplatelet (AP) + anticoagulant (AC) therapy, and 3) AC vs AP+AC therapy. Relevant results and statistics were extracted to determine differences in the rates of the following outcomes: 1) restenosis, 2) occlusion, 3) target limb revascularization (TLR), 4) major amputation, 5) major adverse cardiac events (MACEs), and 6) all-cause death, and 7) bleeding.Studies suggest that DAPT reduced post-surgical restenosis, TLR, and amputation for diabetic patients, without increasing major bleeding incidences, compared to MAPT. Also, AP+AC therapy provided an overall superior efficacy, with no difference in bleeding incidences, compared with antiplatelet alone, and the effects were significant for restenosis, limb salvage and survival rates and cumulative rate of above ankle amputation or death. These results suggest that treatment with DAPT and AP+AC may provide better outcomes than MAPT following the endovascular intervention for CLI. Further large controlled studies are warranted to confirm these outcomes.