ZnO nanocrystalline is a promising candidate for industrial applications. Therefore, there has been an increased attention synthesizing nanocrystalline size ZnO powders. A number of methods have been used for synthesizing ZnO nanopowders by both physical and chemical processes, including sonochemical and microwave-assisted synthesis, refluxing method, hydrothermal method and vapor transport process. These synthesis methods involve complex procedures and complicated equipment. Among these, microwave synthesis is a synthesis method which entirely different from the other method. Microwave assisted hydrothermal synthesis (MW-HTS) method has attracted attention in fabrication of Copper (Cu) doped ZnO nanostructures. ZnO:Cu nanopowders were produced zinc acetate dihydrate as the zinc cation precursor, copper (II) acetate monohydrate as the dopant source and sodium hydroxide as the hydroxide anion source. The effect of Cu content on the structural, morphological and optical properties of ZnO nanopowders was investigated. The effects of Cu content on the crystalline structure and orientation of the nanopowders have been investigated by X-ray diffraction (XRD) study. The lattice parameters and texture coefficient values of ZnO nanopowders were calculated. Field emission scanning electron microscope (FESEM) was used to analyze the surface morphology of the ZnO:Cu nanopowders. The molecular bonding characterization of the ZnO:Cu nanopowders was also determined by Fourier transform infrared spectroscopy (FTIR)