Sechene Stanley Gololo, holds a Ph.D degree in Biochemistry and is currently attached to the department of Biochemistry at Sefako Makgatho Health Sciences University. Dr Gololo is an emerging Scientific Researcher with several publications in scientific journals. Dr Gololo has a research interest in the phytochemical composition and biological activites of medicinal plants used by local traditional healers in South Africa. He has experience in the isolation and identification of bioactive compounds from plant extracts.Currently, Dr Gololo is investigating the effect that environmental factors have on the phytochemical composition of medicinal plants in South Africa.
Prof. Stoycho Stoev is currently a Head of Dept. of General and clinical pathology in Fac. of Veterinary medicine of Trakia University in Bulgaria. He has been a Project leader of 4 international research projects (regarding mycotoxic nephropathy in farm animals and humans) funded by National Science Fund of Ministry of Science and Education in Bulgaria; Bulgarian Project Leader of Joint Research Project between Bulgaria and UK funded by The Royal Society - London (1997-2000); The main Pathologist in eight Joint International Research Projects between Bulgaria and Germany funded by International Pharmaceutical Strategies and Solutions (IPSS) GmbH – Germany (2005-2007); Marie Curie Outgoing International Fellow in University of Johannesburg and Rhodes University in S. Africa under the project addressed the cause of porcine/chicken/human nephropathies in Bulgaria and South Africa (2007-2008 in FP6 of EU and 2013 in FP7 of EU) and Marie Curie Fellow in the Institute of Nuclear Medicine and Allied Sciences (INMAS) in Defence Research and Development Organisation (DRDO) in India under the project studied some herbal additives giving partial protection against toxic or immunosuppressive effects of some mycotoxins (2014 in FP7 of EU); Coordinator of Marie Curie PIRSES project “HERBAL PROTECTION” of FP7 of EU between Bulgaria, Hungary, India and South Africa (2013-2016). He has specializations in Imperial College of Science, Technology and Medicine - London, U.K (1998 - Royal Society project) and in Laboratoire de Toxicologie et S?curity Alimentaire, Toulouse, France (2000 - NATO grant) and many specializations or invited lectures at several universities in Hungary, S. Africa and India. Recently he was a Visiting Professor in Department of Food Technology of Faculty of Science at the University of Johannesburg (2013-2016). He has more than 100 publications in peer reviewed international journals, international books or chapters of books and above 1400 quotations of the same publications
The inhibitory effects of five commercial extracts (Allium sativum, Chamaemelumnobile, Thymus vulgaris, Zingiberofficinale and Ricinuscommunis ) against Alternariaalternata were tested three concentrations (2.5, 5, 12.5 Âµl/ml) in vitro. T. vulgaris and R.communis extracts both exhibited the most effective antifungal activity against A. alternate with diameter of inhibition zones of 54 mm. The C. nobile extract exhibited a lower degree of inhibition 24.5 to 45 mm at three concentrations. The antifungal indices of T. vulgaris and R.communis extracts at three concentrations against A. alternata were all 98.14%, while this of C. nobileextractwas43.52% at 12.5 Âµl/ml. The results show that the five commercial extracts have potential for the development of natural antifungal agents, which could be an alternative to chemicals for control of phytopathogenic fungi on fruits or vegetables. Keywords: commercial extracts, antifungal activities, Alternariaalternata
Bachir Raho Ghalem has completed his PhD in 2011 from Sidi bel Abbes University. He is the Co-Director of Process Engineering and Chemistry of Solutions Laboratory, University of Mascara, Mascara, Algeria. He has published more than 50 papers in reputed journals and has been serving as an editorial board member of repute.
Analyzing the properties of the â€œReconciliation Vesselâ€, new questions arised about its origin, as its configuration through the philosophical and cosmological basis of Traditional Chinese Medicine. Scrutinizing its location within Fu Hisâ€™s octogram and according to the Yellow Emperorâ€™s coincidences in Ling Shu; Su Wen and I-Ching quotations, a plausible explanation raised up from current detailed methodological work, arising the possibility of more widespread cardiac arrests recoveries after both basic and advanced CPR terminal diagnosis.
Dr Inchauspe, medical doctor graduated in Medical Sciences, National University of La Plata, 1986. Scholarship in Germany after surgical residency in 1991, certified in laparoscopic surgery at Aachen and Tubingen Universities. Graduate in Telesurgery at Louis Pasteur University-Strasbourg-, was chosen for the Argentine National Invention Award in 1998. Serving as a teacher in the Argentine Acupuncture Society and as session chairman at several International Congresses since 2005. Invited Foreigner Professor - China National Academy of Medical Sciences Editorial member and reviewer in renowned journals; has been researching about Yongquan resuscitation for 30 years.
Embracing Yoga for Chronic Pain Management is based the presenterâ€™s individual case study Yoga as Therapy for Neurodegenerative Disorders: A Case Report of Therapeutic Yoga for Adrenomyeloneuropathy, and the Yoga for Arthritis (Y4A) protocol developed by yoga researcher and arthritis expert Steffany Moonaz, PhD, along with an interdisciplinary team, including rheumatologists, psychologists, public health researchers and yoga therapists. The case report presents a therapeutic yoga protocol for chronic pain management and its effect on a patientâ€™s quality of life, agility, balance and peripheral dexterity. The report describes concepts and methods of employing therapeutic yoga for healthcare and wellness providers to support clients with chronic pain and neurological disorders at low risk and low cost. Combining ancient yoga practices with modern medical knowledge, the Y4A program offers modifications to address the unique abilities and limitations of persons with arthritis. In a 7-year randomized clinical trial at Johns Hopkins University, the Y4A programâ€™s participation was associated with improved arthritis symptoms, physical fitness, psychological functioning and quality of life. Such evidence is vital for bridging the integrative yoga world with medical healthcare, making these practices more accessible to those who really need them. In 2014, the Yoga for Arthritis protocol was adopted by the National Institutes of Health, National Institute for Arthritis, Musculoskeletal and Skin Disease (NIAMS) for a pilot feasibility study of Yoga as self-care for arthritis in minority communities, of which the presenter served as the primary interventionist (yoga instructor).
Charlene Marie Muhammad is a traditional healing practitioner, who has been embracing the spirit of natural living for over 25 years. Charleneâ€™s practice is predicated on formal Masterâ€™s level training as well as her own personal use of plants, food as medicine and movement therapy, giving her hands-on relationship and knowledge of these traditional healing modalities. Charleneâ€™s traditional healing service, Urbanherbalist, focuses on supporting clients with a practical application to optimal health by using the healing tools that she has grown to embrace in her own personal life: herbal medicine, nutrition and yoga. Charlene is also an early childhood educator and Yoga therapist. A graduate of Cornell University, Charlene holds a Masterâ€™s of Science Degree in Herbal Medicine from Maryland University of Integrative Health and is a Licensed Dietitian. Charlene is also a yoga instructor with over 1000 hours of yoga teacher training and specializes in yoga as therapy.
Rabies is a deadly zoonotic viral disease. It is a major public-health problem which presents huge economic and health burdens in most parts of the developing world. The disease is difficult to treat once the clinical manifestations start to develop; the vaccines produced in mammalian neural tissues have the disadvantage of causing severe adverse reactions. This leads to the practice of traditional medicine for the control of rabies in most parts of Ethiopia for many years. The aim of this review is to give an insight into some of the most commonly used folkloric plants and their method of preparation for the management of rabies. Data for this review were generated from the published research findings on Ethiopian traditional medicinal plants on indifferent peer reviewed journals and proceedings using search words, Rabies in Ethiopia, medicinal plants, Ethno botanical studies and anti-rabies activity. Descriptive analysis was conducted using excel spreadsheets and the numbers of plants species and families were reported in frequency tables and figures. Results: Results showed that a total of 199 plant species belonging to 47 families were used for the management of rabies. The most commonly used families were ephorbiacea stood first, followed by phytolaceae, cucurbitaceae, acanthracea, fabaceae and solianaceae. Phytolacadodecandra, Justicaschimperiana, Recinuscommunis, Bruceaantidysenterica, Croton macrostachyus and Cucumisficifolius were the most cited medicinal plant species utilized for the management of rabies. The most widely used plant part for the preparations of remedy were roots followed by leaves, used in solution form by using water as a most cited solvent. This review indicated that there are many plants utilized for the management of rabies. Hence further research is recommended for ascertaining the efficacy, safety and quality of the claimed medicinal plants. There is also recommended to strengthen the documentation of the indigenous knowledge which contributes for the drug development used for the management of rabies.
Hiwot has completed her masters from Addis Ababa University, Ethiopia. She is public health officer at Africa union(AU) in the department of Africa Center for Disease Control (Africa CDC),Eastern Africa Regional Collaborating Center (ERCC). She is engaged on regional and continental disease prevention and outbreak control activates. Previously she worked as an associate researcher at Ethiopian Public Health Institute, Addis Ababa, Ethiopia. She was contributing on both basic and applied researches.
Background: In the international auriculotherapy practice there are relatively big differences in the exact localization of the same earacupuncture point. On one hand, there are specialists who devote their efforts to find the active points. In that case it becomes intriguing that there may be another point (at 1-2 mm distance) near the point to be treated, indicating a relatively strong, even stronger activity than the one they were initially aiming to find. That point may be active because of another health problem. On the other hand, it may also occur that the same acupuncture point is localized 10-20 mm away from its correct place. Owing to the inaccurate localization, the treatment will nothave the expected effect to the earacupuncture point indications and will cause disappointment to the patient and frustration to the therapist. The â€™SzÃ©chenyi Orientation Ear Mapâ€™ offers a solution to the internationally debated problem of the adequate localization and standardization of earacupuncture points. The ear map offers a solution for finding the exact location of acupuncture points in one uniform/flexible arrangement in various earacupuncture systems, from the Chinese or Nogierâ€™s earacupuncture points to SzÃ©chenyiâ€™s 191 earacupuncture points. It is important to emphasize that apart from the correct diagnosis, the basis of successful therapy is finding the adequate localization of the acupuncture points. Methods:We localize the acupuncture points on a comparative basis, that is to say, we use relative localization. To attain this, we put to use the anatomical formulas of the ear. Further more, the orientation points, the main orientation lines and the auxiliary orientation lines help determine the exact localization. Results: The exact place of the acupuncture point determined with the aid of the orientation map and the relative localization spot will always be at the same place. Using this method one soon discovers that ever year has basically the same shape. Thus, it can be avoided that within the same or in different countries minimum 2 points from among the National Acupuncture Detoxification Association (NADA) or Battle field (BLF) 5 ear points get to an unlikely position or 15-20 mm further away on the top of the ear. It is important not to mix the positions as it is not the same if the needles are inserted in the Allergy point instead of the Omega 2 point, or Zero point will take the place of the Liver point. Conclusions: The orientation points, the main- and auxiliary orientation lines will unambiguously help the therapist to accurately localize the acupuncture points, no matter the shape of the ear. Further more, they also enable to better comprehend the location of those points on different maps. Therapists will not come to a dead-end by trying tofind the active points, and meanwhile end up treating a point responsible for another health problem instead of treating what they aim for. Consequently, it is important to be able to identify the proper location of the active points in question.
Back to nature is a new move in the modern world. This move is counteracted by opponents who enumerate adverse effects for using herbs as a main source of health care remedy. Most of these adverse effects are not belong to the herb by itself, nor to the active constituents. Many researchs attributed these adverse effect to the bad storage conditions that support the growth of microorganisms. Most common are Fungi, which upon growth on the dried stored herb in presence of moisture can elaborate huge aount of toxines known as mycotoxines. Mycotoxines can lead to sever adverse reactions and side effect and even suspect the user to the hazardous pathological disorders lead to cancer. Storage condition should be restrictly encountered as a limiting factor in preparing natural herbal medicine. Otherwise, herbal medicine can be a toxin not a remedy.
Prof. Amany El-Sharif Dean Faculty of Pharmacy Al-Azhar University, Regional Director of North Africa Office of Association of African Universities (AAU -NARO). She is a Prof. of microbiology & immunology. The former Director of training sector in National Authority of Quality Assurance & Accreditation of Education (NAQAAE). El-Sharif is the author of an Arabic book seires titles â€œback to natureâ€, where she is excavating the cultural heritage on folk medicine and using natural resources as food, natural components, energy and body points to find out how to boost immune system naturally. El-Sharif is an editor and reviewer in many peer reviewed international journals in the medical sciences field. She is also a DAAD Aluminous and founder of different public health awareness initiatives.
Background: Moxa floss, the main materials of moxibustion, is made of Chinese mugwort leaves (Artemisia argyi Levi. et vant.). For thousands of years, traditional Chinese medicine experts have believed that aged moxa floss is the best choice for moxibustion. Objective: In this study, by comparing the difference of volatile oil content in different quality of moxa floss,we explored a method for identifying new and aged moxa. Method: The study collected 25 moxa floss samples with the time span of 10 years. We uses gas chromatography(GC) and gas chromatography-mass spectrometry(GC-MS) to investigate the content of moxa volatile oils. Results: GC-MS was used to quantitatively analyze the volatile oil of Moxa floss. The peak area was used to determine the 7 components with higher content and more correlation in moxa floss. The external standard method was used to determine the content of the above 7 volatile oils (eucalyptol, thujone, borneol, Î±-terpineol, eugenol, caryophyllene and caryophyllene oxide) in moxa floss. The results showed that the volatile oil content of the new moxa made from mugwort leaves stored for less than one year was relatively high, and the volatile oil content of aged moxa floss made from dried leaves for more than one year was low. Conclusion: After a short period of the production of moxa floss, new and aged moxa were significantly different, which can better distinguish new moxa floss.
Xin Hui is studying for a doctor's degree in Beijing University of Chinese Medicine. She is mainly engaged in the research of moxibustion mechanism and moxa floss standardization. At present, he has published 2 SCI articles as the first author.
Tomato leaf miner, Tuta absoluta (Meyrick) is a devastating pest of tomato originating from South America which has been recorded in Ethiopia throughout tomato growing areas since 2012. The larvae damages the above ground parts of the plant especially leaf and fruits from seedling stage to maturity. Studies were conducted between 2015 and 2016 for two seasons to screen medicinal plants for the management of T. absoluta under laboratory and glasshouse conditions. Crude extracts of Phytolacca dodecandra seed and leaf, Allium sativum, Nicotiana species, Cymbopogon citrates and Azadirachta indica seed were evaluated at 5, 7.5, and 10% concentrations in the laboratory. Treatments which were found to be the best in the management of T. absoluta under laboratory condition were further evaluated for their efficacy under glass house condition. The mean percentage mortality of larva was recorded for 120 h after treatment application under laboratory study. The highest larval mortalities of 98.33, 96.67 and 95% were recorded for A. indica, C. citrates and A. sativum all at 10% concentration, respectively. In glasshouse experiment, A. indica gave the highest larval mortality of 66.54 % and the lowest percent mortality was recorded in P. dodecandra leaf and seed in both under laboratory and glasshouse conditions. With the obtained results, it can be concluded that foliar application of the mentioned medicinal plants extract on tomato plants reduced T. absoluta population and improved the quality and quantity of tomato fruit yield. Key words: Medicinal plant, Tuta absoluta, Lycopersicon esculentum, crude extracts, efficacy, concentration.
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An herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos (SL for short) is traditionally used for treating melanoma. We have shown that an ethanolic extract of SL (SLE) exerts anti-melanoma effects and suppresses STAT3 signaling. STAT3 has been linked to the development of immunosuppressive tumor microenvironment. In this work, we investigated whether SLE inhibits melanoma growth by reprogramming tumor microenvironment in mouse and cell co-culture models. In B16F10 melanoma bearing mice, we found that intragastric administration of SLE dramatically inhibited tumor growth and angiogenesis, decreased tumor cell proliferation, and induced tumor cell apoptosis. These observations were associated with down regulation of protein levels of p-STAT3 (Tyr 705) and STAT3-targeted genes. We also observed decreased immune suppressive cytokines and increased Th, Tc and dendritic cells in B16F10 melanomas of the SLE-treated mice. In a co-culture system, composed of B16F10 cells and mouse primary splenic lymphocytes, we found that SLE not only inhibited the proliferation of and STAT3 activation in B16F10 cells, but also increased the percentages of Th, Tc and dendritic cells. In the co-culture setting, SLE down regulated mRNA levels of STAT3-targeted genes in the splenic lymphocytes as well. Over-activation of STAT3 in B16 melanoma cells diminished SLEâ€™s effects in increasing the numbers of Th, Tc, dendritic and NK cells, decreasing the numbers of MDSCs and Tregs, and lowering the levels of immune suppressive cytokines in a co-culture system consisting of B16STAT3C cells (stable cells harboring a constitutively active STAT3 variant STAT3C) and splenic lymphocytes. In summary, these findings indicate that reprogramming immune microenvironment, partially mediated by inhibiting STAT3 signaling, contributes to the anti-melanoma mechanisms of SLE. This study provides further pharmacological groundwork for developing SLE as a modern agent for melanoma prevention/treatment. This work was partially supported by grants NSFC 81673649, HMRF 14150571, NSFC81874356, JCYJ20160229210327924, JCYJ20170817173608483, and FRG2/17-18/032.
YU Zhiling holds a BSc degree in Traditional Chinese Medicine and PhD degree in Biochemistry. Dr. Yu is known for his research in herbal pharmacology, focusing on anticancer, anti-inflammation, anti-fatty liver and melanogenesis modulating herbs. Research interests Pharmacology ,Inflammation ,Cancer,Fatty liver,Melanogenesis ,Herbal medicine.
Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, non-toxic, and presenting fewer side effects than conventional medicine. Scientific knowledge on natural products with functional properties, legislative actions to reduce the use of synthetic compounds, and consumer demand for high-quality products have led to an increase in their applications. This communication aims to illustrate context information on a potential commercial use of nutgalls from Quercus infectoria extract. Several aspects related to medical challenge are discussed. Our studies elucidated that the gall exhibited broad spectrum antibacterial, anti-oxidant, and anti-inflammatory activities. Clinical studies on an application of nutgalls as a topical medication for hard-to-heal chronic diabetic ulcers were investigated. Formulations from the ethanol extract of nutgall at concentration 30% with different ratios of pharmaceutical ingredients were tested for antibacterial activity. In clinical trials, fifty one voluntary patients with chronic diabetic ulcers were randomized into two groups of treatment. Patients in study group received standard wound treatment plus QiF10 solution once daily, whereas controls received standard wound treatment alone. Within 4 weeks, 30% of the patients in the study group demonstrated complete wound healing, compared with 4% in the control. Eighty percent of the patients in the study group had complete wound healing while only 20% complete healing were noted in the control by the end of three month. With antibacterial and antioxidant activities, as well as the ability to enhance the wound healing process, QiF10 could be a novel alternative treatment for curing infected chronic wounds.
Supayang received her B.Sc. (Hons) and Ph.D. from the University of New South Wales, Australia. She is currently a Professor in Microbiology and Director of Natural Product Research Center of Excellence, Prince of Songkla University, Thailand. Almost 200 articles were published, with more than 20 patents. Invention Awards were given by National Research Council of Thailand in 2003 and 2014. In 2015, product prototypes won medals from Inventions Geneva and Brussels Innova. She received Research Excellence Awards at Thailand National Research Universities Summit in 2013 and 2014 and named as National Outstanding Researcher in 2014. From 2015-present, she was honored as Thailand Research Fund (TRF) Senior Research Scholar. In 2016, she was selected as National Outstanding University Professor. TRF Annual-Outstanding-Research was awarded in 2018.
There is a growing demand for alternative or complementary medicine in health care disciplines that uses non-invasive instrument to evaluate the health status of various organs inside human body. In this regard, we propose a real-time, non-invasive, and painless technique to assess an individualâ€™s health condition. Our approach is based on the philosophy of Traditional Chinese Medicine (TCM), which classifies the main organs of the human body into five categories to assess the health condition or status of internal organs. In addition, we have applied a deep-learning method along with the combination of iridology and TCM to predict the possible organ dysfunction and give advice to subjects about how to take care of their health according to the body constitution assessment. We used several pre-trained models such as AlexNet, VGG19 and InceptionV3 to classify the body constitution using iris images. In the experiments, the CASIA-Iris-Thousand database is used to perform this task. Experimental results showed that the proposed iris-based health assessment method achieved 88% accuracy.
Holon medicine is a developed medical concept under Holon philosophy and it is broader and deeper than integrative medicine. A Holon is something that is simultaneously a whole and a part. Since a Holon is embedded in larger wholes, it is influenced by and influences these larger wholes. And since a Holon also contains subsystems, or parts, it is similarly influenced by and influences these parts. In the case of a medicine, medical system refers not only to healthcare incorporating a variety of systems and treatments, applied in combination with those medical modalities to treat and prevent illnesses, or enhancing health but also it is considered interactions between nature, earth, space and cosmic influences and human physiology and diseases. The benefits of this new medicine model are mainly upon highly effectiveness of healthcare and economy in medical expenditure. Other anticipated advantages of Holon concept in medical systems are outstanding holistic approaches, development of applied principles and methods, interchanges of medical and health cultures. Aromatherapy is one of wide spreading alternative medicine not only in conventional health care system but in general life style. This means aromatherapy has variable and adaptable attribute in nature and easiness to integration with other therapeutic modalities. Also aromatherapy specially became a necessary medical system to promote health and to increase QOL in old aged society. Benefits of aromatherapy integrated with others are producing synergic effects, variability and multiplicity of practices, enhanced harmony and balance of functions, expanded use of East-West herbals and essential oils, development and applies that not be found its efficacy if it is alone and brain centered therapeutic approaches. In this topic, it will be reviewed aromatherapy in view of Holon concept as integrating total care of patients as aspects of mental health (spiritual), physical health and cultural influences combined with social health.
There is a growing epidemic of chronic disease affecting our families. if we continue on the current trajectory, 80% of adults and children will have a diagnosed chronic health condition by 2025 and 1 in every 4 children born will have autism by 2033! Mental health/Brain problems/Mental instability are also on a rise, we are losing our quality of life. As in the United States, almost half of adults (46.4 percent) will experience a mental illness during their lifetime. The World Health Organization (WHO) estimates that each year approximately one million people die from suicide, which represents a global mortality rate of 16 people per 100,000 or one death every 40 seconds. It is predicted that by 2020 the rate of death will increase to one every 20 seconds! 1 in 6 U.S. youth aged 6-17 experience a mental health disorder each year. Suicide is the 2nd leading cause of death among people aged 10-34. Join Madiha Saeed, MD for a one of a kind symposium on understanding how we can lower inflammation and heal and prevent chronic disease in all ages.
Traditional Chinese Medicine (TCM) has a long and rich history, and it is one of the oldest cultures in the world which its medicine is formed by continuous practice. It has been evolving after more than 2,000 years of clinical observation.TCM has been playing an irreplaceable role in China's medical health system, and continues to provide medical services to patients. External therapy is one of the classifications of TCM treatment methods, and it includes various types such as acupuncture, massage, topical medicine, incision, cauterization with heated needle, etc. Eczema is an allergic inflammatory skin disease with symmetrical distribution of skin lesions, polymorphic damage, severe itching, and tendency to exudates, recurrent attacks, and chronicity. Clinically, it is usually divided into acute, sub acute and chronic categories according to the length of the disease. This article mainly discusses the effect of using acupuncture plus lithospermum root ointment on chronic eczema. After long-term clinical observations, acupuncture at Xuehai (SP10), Baizongwo (EX-LE2), Yinlingquan (SP9), Taichong (LR3), Quchi (PC3), Baihui (DU20), Sishenchong (EX-HN1) and the surrounding of affected area can reduce the number of attacks and reduce the degree of itching in patients with chronic eczema. According to the ancient Chinese book "Compendium of Materia Medica", the roots of lithospermum have the effect of "treating spotted rash and pox, promoting blood circulation, anti-inflammatory, and laxative." TCM clinic uses it to make lithospermum root ointment to apply to eczema. Here we mainly treat eczema patients who have been diagnosed with eczema by western medicine for more than 1 year and have prescribed steroids for external use, and show ineffective outcome. Clinical records show that acupuncture combined with lithospermum root ointment has four effects on this type of chronic eczema: control skin surface inflammation, promote healing of skin lesions, reduce frequency of itching and reduce level itching. It is hoped that it can provide a very good treatment for patients suffering from eczema for a long time, and also let other medical systems in the world understand the external treatment of Chinese medicine. Medicine should not have boundaries, as long as it is an effective method it should have opportunity to contribute to others. Keywords: Traditional Chinese Medicine, acupuncture, lithospermum root, External Therapy, Eczema
Objective/Purpose:Strychnos madagascariensis is a wild indigenous fruit consumed by the people living in the northern coastal region of Kwazulu Natal, South Africa with the claim to curb diabetes and hypertension. However, attention has not been giving to its nutritional value as well as the scientific appraisal regarding its use in traditional medicine.Hence, this study investigated the phytochemicals, FTIR analysis, proximate, mineral nutrients, anti-nutritional components, antioxidant, antidiabetic potential and cytotoxicity of Strychnos madagascariensis ripefruit. Methods:The fruit parts were screened for their phytochemical components using standard protocols. FTIR spectra analysis was determined using the IR technique. Proximate parameterswere determined using standard protocols. Themineral nutrients were determined using Atomic Absorption Spectrophotometer. Anti-nutrients (phytic and oxalic acid) were determined using the titration method. Different extracts were prepared by maceration using methanol, n-hexane, ethyl acetate, and water, respectively. The antioxidant potential of crude extracts was investigated using ABTS and DPPH radical assays. The in vitro antidiabetic activity of the plant extracts was evaluated using in vitro Î±-amylase, Î±-glucosidase, and pancreatic lipase enzyme assays while the cytotoxicity of the extracts was investigated on H293 and HeLa cell lines using MTT cell proliferation assay. Results:The phytochemical screening revealed the presence of terpenoids, alkaloids and cardiac glycosides in the fruit parts. FTIR spectra analysis of the crude extracts showed the presence of various functional groups such as phenols, alkanes, alkenes, carboxylic acid, nitro compounds, aliphatic fluoro compounds. The fruit parts had high fiber and ash, but low fat and protein contents. The high amount of K, Mg, N, and Fe was detected in the fruit parts. Phytic acid was present in the seed coat (1.39Â±0.01 %) while oxalic acid was not present in both fruit parts.The crude extracts exhibited a different degree of ABTS and DPPH radical scavenging activity. The aqueous, methanolic and ethyl acetate extracts of the fruit parts possessed the highest scavenging ability on ABTS and DPPH when compared to other extracts.In addition, the crude extracts inhibitedÎ±-amylase and Î±-glucosidase activities in a concentration-dependent manner with the methanolic extract possessing the highest activity. Similarly, the crude extracts also reduced the activity of pancreatic lipase with the same methanolic extract. The cytotoxicity of the extracts demonstrated the safe use of the fruit in the management of diabetes mellitus. Conclusion: Results from this study showed that the fruit could serve as a potential nutraceutical in the management of diabetes.